Scientific Lecture: Dr. Vaclav Veverka – July 9 @ 10am (187A)
Title: Biomolecular NMR: an essential tool for drug discovery
IOCB Gilead Sciences Research Centre in Prague
Department of Cell Biology, Charles University, Prague, Czech Republic
Several key stages in the knowledge-based drug discovery process require detailed information about targeted systems at the molecular level. This includes validation of selected proteins or protein-protein interactions and assessment of their druggability, identification of suitable small molecules with the desired inhibitory activity and detailed structural characterization of the sites of intervention essential for the development of initial hits to more active lead molecules. NMR spectroscopy was for a long time overshadowed by X-ray crystallography in drug discovery but with a recent shift in target selection towards more challenging protein-protein interactions it bounced back on stage. The particular strengths of the technique will be introduced from the biologists’ perspective and the benefits for drug discovery illustrated in the context of an epigenetic target.