The study of gene control is at the center of life science and medicine. Proper control of when genes turn on and off is essential to normal health, and a wide variety of human pathology can be attributed to aberrant control of gene expression. Indeed, basic and translational discoveries in gene control have led directly to new therapies and improvements in ameliorating disease. But after a century of important study into the fundamentals of gene control, new technologies are bringing an inflection point to this cornerstone of biomedical science.
Breakthroughs in the disciplines of genetics, computation, and chemical biology are priming our ability to study and manipulate RNA and chromatin regulation – two key areas of gene control with the potential to impact nearly all aspects of human health and disease. BCM possesses established or burgeoning strengths in each of these disciplines, but these areas are not integrated toward therapeutics and disease solutions.
THINC@BCM is nucleated around a single idea: Targeting RNA and chromatin control can avail therapeutic insights in a wide range of human diseases. THINC@BCM integrates 3 key pillars (genetics/genomics, computation, and chemistry) in order to bring together and amplify Baylor College of Medicine talent, facilitate discovery and leadership in this important area of science, and generate therapeutic solutions.